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<?php $str = "var1,'Hello'|var2,'World'|"; preg_match_all('/(?:^|\|)([^,]+),([^\|]+(?=\||$))/', $str, $matches); $new_substr = array_combine($matches[1], $matches[2]); print_r($new_substr);

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34.75 ms | 402 KiB | 5 Q